Epidermal proliferation of nude mouse skin, pig skin, and pig skin grafts. Failure of nude mouse skin to respond to the tumor promoter 12-O-tetradecanoyl phorbol 13-acetate.

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Epidermal proliferation of nude mouse skin, pig skin, and pig skin grafts. Failure of nude mouse skin to respond to the tumor promoter 12- O-tetradecanoyl phorbol 13-acetate

Human skin transplanted to nude mice offers a possible experimental system for the study of normal epidermal proliferation and differentiation, and for their pathological counterparts. Crucial to the development of such a system is the demonstration that such grafts retain the responsive features of donor skin. To document that donor proliferative characteristics are maintained in the grafts, a...

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Ultrastructural, HistolÃ3gica!, and Biochemical Alterations Produced by 12-O-Tetradecanoyl-phorbol-13-acetate on Mouse Epidermis and Their Relevance to Skin Tumor Promotionl

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ژورنال

عنوان ژورنال: Journal of Experimental Medicine

سال: 1980

ISSN: 0022-1007,1540-9538

DOI: 10.1084/jem.152.5.1329